Vidéos Laurent MOTTRON MD & Prof., PhD · LA NOTION MÊME D’AUTISME · Déc. 2020 · Y.c. “Autisme Invisible” & Sex-Ratio : « Douze ans d’errements rectifiés » ➽ & INSAR Journal “AUTISM RESEARCH” Commentary, Mottron “A RADICAL CHANGE in our autism research strategy is needed : BACK TO PROTOTYPES”, 2 June 2021 first published 126·rd130·136

fr Conférences STRAS&ND en français, du 10 et du 11 décembre 2020 · Strasbourg Translational Research on the Autism Spectrum & Neurodevelopmental Disorders · STRASaND.fr · Conférences précurseurs de en l’article publié INSAR Journal “Autism Research”
· Document du mercredi 2 juin 2021
 · Article revu le 5 août 2021


en 2 June 2021, Commentary (article) in INSAR Journal “AUTISM RESEARCH”, Mottron “A RADICAL CHANGE in our autism research strategy is needed : BACK TO PROTOTYPES” ; and Replies

  • + Mottron L, Bzdok D. “Autism spectrum heterogeneity : fact or artifact ?” Mol Psychiatry. 2020 Dec;25(12):3178-3185. doi : 10.1038/s41380-020-0748-y. Epub 2020 Apr 30. PMID : 32355335 ; PMCID : PMC7714694. DOI.org/10.1038/s41380-020-0748-y
Abstract

The evolution of autism diagnosis, from its discovery to its current delineation using standardized instruments, has been paralleled by a steady increase in its prevalence and heterogeneity. In clinical settings, the diagnosis of autism is now too vague to specify the type of support required by the concerned individuals. In research, the inclusion of individuals categorically defined by over-inclusive, polythetic criteria in autism cohorts results in a population whose heterogeneity runs contrary to the advancement of scientific progress. Investigating individuals sharing only a trivial resemblance produces a large-scale type-2 error (not finding differences between autistic and dominant population) rather than detecting mechanistic differences to explain their phenotypic divergences. The dimensional approach of autism proposed to cure the disease of its categorical diagnosis is plagued by the arbitrariness of the dimensions under study. Here, we argue that an emphasis on the reliability rather than specificity of diagnostic criteria and the misuse of diagnostic instruments, which ignore the recognition of a prototype, leads to confound autism with the entire range of neurodevelopmental conditions and personality variants. We propose centering research on cohorts in which individuals are selected based on their expert judged prototypicality to advance the theoretical and practical pervasive issues pertaining to autism diagnostic thresholds. Reversing the current research strategy by giving more weight to specificity than reliability should increase our ability to discover the mechanisms of autism.

Lay Summary

Scientific research into the causes of autism and its mechanisms is carried out on large cohorts of people who are less and less different from the general population. This historical trend may explain the poor harvest of results obtained. Services and intervention are provided according to a diagnosis that now encompasses extremely different individuals. Last, we accept as a biological reality the constant increase over the years in the proportion of autistic people among the general population. These drifts are made possible by the attribution of a diagnosis of autism to people who meet vague criteria, rather than to people who experienced clinicians recognize as autistic. We propose to change our research strategy by focusing on the study of the latter, fewer in number, but more representative of the “prototype” of autism. To do this, it is necessary to clearly distinguish the population on which the research is carried out from that to which we provide support. People must receive services according to their needs, and not according to the clarity of their diagnosis.

  • TY - JOUR
    AU - Amaral, David G.
    TI - Introduction to commentary by Laurent Mottron and responses
    JO - Autism Research
    JA - Autism Research
    SN - 1939-3792
    DO - https://doi.org/10.1002/aur.2530
  • TY - JOUR
    AU - Mottron, Laurent
    TI - A radical change in our autism research strategy is needed : Back to prototypes
    JO - Autism Research
    JA - Autism Research
    SN - 1939-3792
    DO - https://doi.org/10.1002/aur.2494
    KW - diagnostic
    KW - polythetic criteria
    KW - prototype
    KW - reliability
    KW - type 2 error
    AB - Abstract The evolution of autism diagnosis, from its discovery to its current delineation using standardized instruments, has been paralleled by a steady increase in its prevalence and heterogeneity. In clinical settings, the diagnosis of autism is now too vague to specify the type of support required by the concerned individuals. In research, the inclusion of individuals categorically defined by over-inclusive, polythetic criteria in autism cohorts results in a population whose heterogeneity runs contrary to the advancement of scientific progress. Investigating individuals sharing only a trivial resemblance produces a large-scale type-2 error (not finding differences between autistic and dominant population) rather than detecting mechanistic differences to explain their phenotypic divergences. The dimensional approach of autism proposed to cure the disease of its categorical diagnosis is plagued by the arbitrariness of the dimensions under study. Here, we argue that an emphasis on the reliability rather than specificity of diagnostic criteria and the misuse of diagnostic instruments, which ignore the recognition of a prototype, leads to confound autism with the entire range of neurodevelopmental conditions and personality variants. We propose centering research on cohorts in which individuals are selected based on their expert judged prototypicality to advance the theoretical and practical pervasive issues pertaining to autism diagnostic thresholds. Reversing the current research strategy by giving more weight to specificity than reliability should increase our ability to discover the mechanisms of autism. Lay Summary Scientific research into the causes of autism and its mechanisms is carried out on large cohorts of people who are less and less different from the general population. This historical trend may explain the poor harvest of results obtained. Services and intervention are provided according to a diagnosis that now encompasses extremely different individuals. Last, we accept as a biological reality the constant increase over the years in the proportion of autistic people among the general population. These drifts are made possible by the attribution of a diagnosis of autism to people who meet vague criteria, rather than to people who experienced clinicians recognize as autistic. We propose to change our research strategy by focusing on the study of the latter, fewer in number, but more representative of the ?prototype ? of autism. To do this, it is necessary to clearly distinguish the population on which the research is carried out from that to which we provide support. People must receive services according to their needs, and not according to the clarity of their diagnosis.
  • TY - JOUR
    AU - Constantino, John N.
    TI - Response to “A Radical Change in Our Autism Research Strategy is Needed : Back to Prototypes” by Mottron et al. (2021)
    JO - Autism Research
    JA - Autism Research
    SN - 1939-3792
    DO - https://doi.org/10.1002/aur.2529
  • TY - JOUR
    AU - Lombardo, Michael V.
    TI - Prototyping as subtyping strategy for studying heterogeneity in autism
    JO - Autism Research
    JA - Autism Research
    SN - 1939-3792
    DO - https://doi.org/10.1002/aur.2535
  • TY - JOUR
    AU - Mottron, Laurent
    TI - Progress in autism research requires several recognition-definition-investigation cycles
    JO - Autism Research
    JA - Autism Research
    SN - 1939-3792
    DO - https://doi.org/10.1002/aur.2524

fr Playlist YouTube des 6 Vidéos (déc. 2020, précurseurs de l’article juin 2021)


fr Les six Vidéos directement visionnables

Vidéo (i.) · 2020-12-10 · 1/2 · Exposé : L’hétérogénéité de l’autisme en 2020 : nature, ou culture ?

Exposé de Conférence « L’hétérogénéité de l’AUTISME en 2020 : nature, ou culture ? » par Laurent Mottron, Pr Université de Montréal. Exposé le 10 décembre 2020 STRAS&ND, Université de Strasbourg. YouTu.be/-oPRvoWbjSA

Vidéo (ii.) · 2020-12-10 · 2/2 · Discussion : L’hétérogénéité de l’autisme en 2020 : nature, ou culture ?

Discussion après Exposé de Conférence « L’hétérogénéité de l’AUTISME en 2020 : nature, ou culture ? » par Laurent Mottron, Pr Université de Montréal. Discussion le 10 décembre 2020 STRAS&ND, Université de Strasbourg. YouTu.be/PiYos4xKmHw

Vidéo (iii.) · 2020-12-11 · 1/2 · Exposé : La recherche doit-elle privilégier l’autisme que l’on reconnaît sur celui que l’on définit ?

Exposé de Conférence « La recherche doit-elle privilégier l’autisme que l’on reconnaît sur celui que l’on définit ? » par Laurent Mottron, Pr Université de Montréal. Exposé le 11 décembre 2020 STRAS&ND, Université de Strasbourg. YouTu.be/yEw7NGkclWc

Vidéo (iv.) · 2020-12-11 · 2/2 · Discussion : La recherche doit-elle privilégier l’autisme que l’on reconnaît sur celui que l’on définit ?

Discussion après Exposé de Conférence « La recherche doit-elle privilégier l’autisme que l’on reconnaît sur celui que l’on définit ? » par Laurent Mottron, Pr Université de Montréal. Discussion le 11 décembre 2020 STRAS&ND, Université de Strasbourg. YouTu.be/pCFnOWG2usw

Vidéo (v.) — 2 extraits assemblés — 2020-12-10 et 11 · Autisme “Invisible” et Sex-Ratio : « Douze ans d’errements rectifiés »

Les deux Extraits ensemble des Discussions après Exposés de Conférences · Extraits portant sur Autisme “Invisible” et Sex-Ratio : "Douze ans d’errements rectifiés" · par Laurent Mottron, Pr Université de Montréal : Extraits, pour les nuls. Deux extraits assemblés des deux Discussions les 10 et 11 décembre 2020 STRAS&ND, Université de Strasbourg. YouTu.be/uoCsvy-t_kU

Vidéo (vi.) — 3 extraits assemblés — 2020-12-11 · Autisme Prototypique • (Et : Traits Autistiques et Spectre Autistique : à la poubelle)

Autisme Prototypique : les Traits (autistiques) et le ️Spectre (autistesque…) à la poubelle · Exposé par Laurent Mottron, Pr Université de Montréal : Extraits, pour les nuls. Trois extraits assemblés de l’exposé de Conférence du 11 décembre 2020 STRAS&ND, Université de Strasbourg. YouTu.be/B2DWJNBDCBI


Sources

STRAS&ND · STRASaND.fr
Strasbourg Translational Research on the Autism Spectrum & Neurodevelopmental Disorders


Publications

Derniers articles publiés

Navigation

Articles de la rubrique